Hif - 1α
Web12 de jun. de 2024 · Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown. Here, we explored the relationship between HIF-1α and PD-L1 expression in glioma, and investigated their … Web21 de jun. de 2024 · HIF1α（Hipoxia-inducible factor 1 arpha）は、低酸素誘導因子とも呼ばれ、低酸素時（酸素の濃度が低下したとき）にタンパク質の安定性が向上すること …
Hif - 1α
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WebThe oxygen-regulated subunit, HIF-1alpha, is stabilized in cells exposed to hypoxia. The regulation of hypoxic responses by nitric oxide (NO) is believed to have wide … Web13 de abr. de 2024 · Furthermore, chromatin immunoprecipitation (ChIP) analysis and luciferase reporter assays revealed that hypoxia-inducible factor 1α (HIF-1α) specifically …
Web26 de abr. de 2013 · In summary, this study demonstrates the HIF-1α-dependent regulation of HIF-1β under hypoxic conditions for the first time. The results indicate a novel cell … WebM1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which …
Web13 de abr. de 2024 · Mechanistically, MMP2, VE-cadherin, and Vimentin expression were affected. HIF-1α plays an important role in inducing lung adenocarcinoma cell metastasis … Web19 de set. de 2012 · The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization …
Web3 de ago. de 2024 · HIF-1α is the main regulator of hypoxia signaling and is widely expressed (20-22). HIF-1α is involved in the occurrence and development of various liver …
WebHypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits that is present in all metazoan species. The expression and activity of the HIF … grace chen allen txWeb1 de set. de 2015 · Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as well as tumor resistance therapy. It was found that 2 4E-BP1 grace chen actressWebMonoclonal anti-HIF-1α antibody (diluted 1: 500) can be used in immunofluorescence confocal microscopy. It can also be used in in immunoblotting, immunoprecipitation and … grace chem-dryWebRESULTS. Hypoxia-inducible factor 1α and VEGF were expressed in the inner retina of 5/5 untreated PSR eyes adjacent to retinal neovascularization; expression of HIF-1α was not detected (and VEGF only lightly detected) in normal retinal … grace chehalisWeb23 de jul. de 2024 · HIF-1α Antibody (28b) is an IgG 1 κ mouse monoclonal HIF-1 alpha antibody (also designated HIF1A antibody or HIF-1 alpha antibody) that detects the HIF … chili\u0027s waterburyhttp://jms.qdu.edu.cn/Upload/html/59011.htm grace chelmsford massWeb16 de mai. de 2014 · HIF-1α has been carefully studied in the context of severe hypoxic stresses (<1% O 2 ), but it is also known to be present at oxygen tensions commonly found in normal tissues in vivo (∼1–13% O 2 ), albeit at much lower levels. Its role under these physiological conditions is not fully understood. grace cheng npi